Role of Osteoclasts in Radiation Induced Bone Loss

نویسندگان

  • Lauren J. Richey
  • Sureshkumar Muthupalani
  • B. K. Chaffee
  • D. K. Meyerholz
  • S. Ramachandran
  • A. S. Urbasic
  • S. Hynes
  • A. Somrak
  • M. Rahman
  • J. Liu
  • A. L. MacNeill
  • F. Aeffner
  • Z. Traylor
  • E. A. Driskell
  • R. R. Hukkanen
  • Justin Greenlee
چکیده

2:30 p.m. 2:45 p.m. OF MICE, MEN AND PIGS: LOSS OF CFTR PRODUCES ABNORMAL TRACHEAL DEVELOPMENT D.K. Meyerholz, S. Ramachandran, D.A. Stoltz, M.J. Welsh, and P.B. McCray, Jr. Departments of Pathology, Pediatrics, Internal Medicine, Molecular Physiology and Biophysics, and Howard Hughes Medical Institute, Roy Carver College of Medicine, University of Iowa, Iowa City, IA Keyword: Respiratory System, Abstract Number 120

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Differences in responses to X-ray exposure between osteoclast and osteoblast cells

Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced bone resorption by osteoclasts and decreased bone formation by osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating and differentiating osteoclasts were relatively sensitive to X-rays compared with osteoblasts. X-rays decreased cell v...

متن کامل

Trabecular bone changes induced by fast neutrons versus gamma rays in mice

Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and Methods: Serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. Tibiae were anal...

متن کامل

Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss.

Mechanosensing is one of the crucial components of the biological events. In bone, as observed in unloading-induced osteoporosis in bed ridden patients, mechanical stress determines the levels of bone mass. Many molecules have been suggested to be involved in sensing mechanical stress in bone, while the full pathways for this event has not yet been identified. We examined the role of TRPV4 in u...

متن کامل

Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse.

Exposure of astronauts in space to radiation during weightlessness may contribute to subsequent bone loss. Gamma irradiation of postpubertal mice rapidly increases the number of bone-resorbing osteoclasts and causes bone loss in cancellous tissue; similar changes occur in skeletal diseases associated with oxidative stress. Therefore, we hypothesized that increased oxidative stress mediates radi...

متن کامل

P-181: Protective Role of Vitamin E As An Alternative Treatment for Ovariectomized Osteoporotic Rats

Background: Osteoporosis one of the postmenopausal symptoms is characterized by bone loss. There is a link between excessive reactive oxygen species (ROS) formation, estrogen deficiency due to cessation of ovarian function and bone loss. Free radicals are responsible for causing osteoblast apoptosis and reducing osteoblastogenesis in bone remodeling. Vitamin E is a potent antioxidant with the a...

متن کامل

Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays.

Bone loss is a consequence of exposure to high-dose radiotherapy. While damage to bone vasculature and reduced proliferation of bone-forming osteoblasts has been implicated in this process, the effect of radiation on the number and activity of bone-resorbing osteoclasts has not been characterized. In this study, we exposed mice to a whole-body dose of 2 Gy of X rays to quantify the early effect...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010